Ace Suppository 500mg 1pc

✔️ Syrup/Suspension:

• <3 months: 10 mg/kg (or 5 mg/kg if jaundiced), 3–4 times daily
• 3 months–1 year: ½–1 teaspoon, 3–4 times daily
• 1–5 years: 1–2 teaspoons, 3–4 times daily
• 6–12 years: 2–4 teaspoons, 3–4 times daily
• Adults: 4–8 teaspoons, 3–4 times daily

✔️ Tablet:

Adults: 1–2 tablets every 4–6 hours (maximum 4 g/day).

Children (6–12 years): ½–1 tablet 3–4 times daily (max ~2.6 g/day for long-term use)

✔️ Extended-Release Tablets:

• Adults & children ≥12 years: 2 tablets every 6–8 hours (max 6 tablets/day); swallow whole

✔️ Suppository:

• 3–12 months: 60–120 mg, up to 4 times daily
• 1–5 years: 125–250 mg, up to 4 times daily
• 6–12 years: 250–500 mg, up to 4 times daily
• ≥12 years & adults: 500 mg–1 g, up to 4 times daily

✔️ Paediatric Drops:

• Up to 3 months: 40 mg
• 4–11 months: 80 mg
• 1–2 years: 120 mg
  (Maximum 5 doses/day for up to 5 days)

✔️ Fast-dissolving (Actizorb) Tablets:

• Adults & ≥12 years: 1–2 tablets every 4–6 hours (max 8/day)
• Children (7–11 years): ½–1 tablet every 4–6 hours (max 4/day)

✔️ IV Infusion:

• ≥50 kg: 1000 mg every 6 hours or 650 mg every 4 hours (max 4 g/day)
• <50 kg: 15 mg/kg every 6 hours or 12.5 mg/kg every 4 hours (max 75 mg/kg/day)
• Children (2–12 years): same as weight-based dosing above

✔️ Overdose may cause serious liver damage:

Early symptoms (within 24 hours):

• Nausea, vomiting, loss of appetite, abdominal pain

Later complications:

• Liver failure, metabolic acidosis, encephalopathy, renal failure, and possible death

Management:

• Immediate medical treatment is essential
• Activated charcoal (if within 1 hour)
• Antidote: N-acetylcysteine (most effective within 8 hours)
• Oral methionine may be used if IV treatment is unavailable

✔️ Special Population

• Pediatric: Safe and effective (including IV form for ≥2 years)
• Elderly: No significant difference in safety or efficacy
• Hepatic impairment: Avoid in severe liver disease; dose adjustment may be required
• Renal impairment: May require dose reduction or extended dosing interval

✔️ Interaction

• Reduced metabolism may occur with barbiturates, tricyclic antidepressants, and alcohol
• Alcohol increases the risk of liver toxicity
• Enzyme inducers (e.g., anticonvulsants, oral contraceptives) may reduce the therapeutic effect

✔️ Side Effects

• Blood disorders (e.g., thrombocytopenia, leukopenia)
• Skin rashes and allergic reactions
• Rarely pancreatitis

✔️ Contraindications:

Hypersensitivity to paracetamol or any component

✔️ Pregnancy & Lactation

• Considered safe in recommended doses during pregnancy under medical advice
• Excreted in breast milk in small amounts; generally compatible with breastfeeding

✔️ Precautions & Warnings

• Use cautiously in patients with liver or kidney impairment
• Higher risk of toxicity in chronic alcohol users
• Avoid exceeding recommended doses to prevent severe liver damage
• Do not take with other paracetamol-containing products
• Use only when clearly necessary

Serious allergic reactions (including anaphylaxis) are rare but require immediate discontinuation.

✔️ Storage:

• Store in a dry place below recommended temperature
• Protect from heat and light
• Keep out of reach of children